There are two matches on Saturday as the action kicks-off with two surprise finishers from 2015/16, Platinum Stars and Chippa United, doing battle at the Royal Bafokeng Stadium.
Both were winners in midweek league action beating SuperSport United (1-0) and Free State Stars (2-1) respectively.
Two more teams that started the season with league wins, Bidvest Wits and Orlando Pirates, then lock horns in the late game at the Bidvest Stadium.
Gavin Hunt’s men beat Chiefs, while the Buccaneers and their new coach Muhsin Ertugral eased to a 3-1 triumph over Lamontville Golden Arrows.
The Turkish coach is relishing the battle against Hunt, but concedes it will be tough.
“It’s always difficult,” he said. “Gavin is a friend of mine and I have great respect for him as a coach and a human being.
“We have come a long way together as friends, but it’s never easy to play against him. He has a very organised team; I watched them against Kaizer Chiefs.”
The Students ended the league second last year and Pirates were a poor seventh.
Finally, reigning league champions Mamelodi Sundowns play their first domestic match of the season on Sunday when they host SuperSport United, eighth last year, at Loftus Versfeld Stadium.
The Brazilians did not play in the league as they had CAF Champions League commitments.
They rounded off the group stages of the competition when they were beaten 3-1 by Enyimba of Nigeria in midweek, a result that little to stop Pitso Mosimane’s men from reaching the semi-finals as pool winners.
Matsatsantsa on the other hand will be desperate to bounce back after falling to that surprise loss to Stars on Wednesday