Louis Van Gaal’s Manchester United will face Danish side Midtjylland in the round of 32 of the Europa League after dropping out of the Champions League group stage.
Going for a hat-trick of UEFA Europa League triumphs, Sevilla will play Molde in the round of 32, while Fiorentina and Tottenham meet again. Liverpool boss Jurgen Klopp will make a return to Germany as the Reds play Augsburg.
New Valencias manager Gary Neville will begin his journey as a coach in Europe with the tie against Rapid Vienna from Austria.
The first legs are provisionally scheduled for 18 or 25 February, with the return legs on 10 and 17 March.
All three English clubs will be at home for the second leg because they were seeded.
Spurs and Liverpool qualified after winning Group J and B respectively, while United finished third in Champions League Group B.
Round of 32 draw
Valencia (ESP) v Rapid Wien (AUT)
Fiorentina (ITA) v Tottenham Hotspur (ENG)
Borussia Dortmund (GER) v Porto (POR)
Fenerbahçe (TUR) v Lokomotiv Moskva (RUS)
Anderlecht (BEL) v Olympiacos (GRE)
Midtjylland (DEN) v Manchester United (ENG)
Augsburg (GER) v Liverpool (ENG)
Sparta Praha (CZE) v Krasnodar (RUS)
Galatasaray (TUR) v Lazio (ITA)
Sion (SUI) v Braga (POR)
Shakhtar Donetsk (UKR) v Schalke (GER)
Marseille (FRA) v Athletic Club (ESP)
Sevilla (ESP) v Molde (NOR)
Sporting CP (POR) v Bayer Leverkusen (GER)
Villarreal (ESP) v Napoli (ITA)
St-Étienne (FRA) v Basel (SUI)
*First leg 18.00CET, 16 February (Fenerbahce game)
**Second leg 18.00CET, 24 February (Braga game)