Manchester City fear Sergio Aguero and David Silva are both out of the Manchester derby and their Champions League tie with Sevilla.
Aguero fears he will be out for at least a month after suffering a hamstring tear playing for Argentina while Silva sprained ankle ligaments playing for Spain on Friday.
Aguero lasted just 22 minutes of Argentina’s 2-0 defeat to Ecuador.
‘I think I’ll be a month without playing,’ Aguero said. ‘I’ll go to the AFA national team compound to carry on with treatment. To recover from the tear I’ll surely need a month.
‘I’d been playing very frequently and was in doubt [for Thursday’s match] until the last minute, but as a player you always want to be there and never know what can happen.’
The Argentine FA confirmed in a statement: ‘The studies we did today show that Sergio Aguero has a Grade Two muscle tear.’
A Grade Two tear can require anything from two to eight weeks to recover from and the striker has a history of hamstring problems.
He was replaced as a precaution after his five-goal haul against Newcastle last week and later admitted he had felt his hamstring in City’s previous game against Borussia Monchengladbach.
City’s problems were compounded on Friday as Silva came off after just seven minutes of Spain’s 4-0 win over Luxembourg with a sprained ankle and was ruled out for two to three weeks.
Spain confirmed Silva had suffered ‘a bad sprain of the internal lateral ligament of the right ankle’. Silva has only just returned to action after a calf injury.