Chelsea will visit Goodison Park to face Everton, after beating a second string Manchester City side, in a replay of the 2009 final, where ironically, Guus Hiddink was also in charge.
The Dutchman won the trophy during his first interim spell at Stamford Bridge, beating the Tofees 2-1.
Reigning FA Cup champions Arsenal will face Premier League rivals Watford if they win their fifth round replay against Hull City.
The Gunners were held to a goalless draw by the Tigers on Saturday, prompting a replay, but will fancy their chances of making it to Wembley if they can scale past Hull.
Manchester United, meanwhile, will host another Premier League side, West Ham United if they negotiate past League One side, Shrewsbury Town on Monday night.
The Red Devils have failed to beat the Hammers when both sides have faced in the Premier League this season, and with West Ham strongly challenging them for fifth place on the table, they will know they have their work cut out if they beat Shrewsbury.
Championship side Reading will bid to reach Wembley for the second consecutive year and continue their impressive run in the competition when they host Crystal Palace.
Reading have only lost one FA Cup tie in their last 10 outings in the competition, which was last year’s semi-final defeat to Arsenal.
The full draw:
Reading vs Crystal Palace
Everton vs Chelsea
Arsenal or Hull vs Watford
Shrewsbury or Manchester United vs West Ham
Ties to take place between the 11th and 14th of March